StingingVelvet: They actually made a point NOT to support a controller, which is amusing.
Fenixp: Yeah, the original Mass Effect came out at the time when there still were chances that PC master race would turn a full controller support in a hardcore RPG agains them. Grr. It pisses me off, because I know my wife would love Mass Effect games, she just refuses to play stuff using M+K that is not turn-based strategy.
Well, I'm lucky enough to have them as CE versions on 360, I'm guessing they work like SWKOTOR on PC where the combat kind of pauses 'til you make your selections, so maybe that would suit her if it was so?