SupahGamuh: I too have a bit of a problem with Tyrian 2000.
The game runs pretty good and I actually like the soundtrack, especially in FM mode, it reminds me a lot of the good days of the 16 bit consoles. BUT...
When I try to actually play the game, the ship always goes to the right of the screen and I'm always struggling to get it to the left side, even when I navigate through the options like, say, the music, the bar will always go up as if I pressed right.
I'm completely inexperienced on DOS-Box as many old games I like already have a decent source port that works right away, so, if it's any configuration for DOS-Box, I don't even know where to begin with.
It does look like it's something about my mouse or my keyboard, I can't really tell.
EDIT: Fogot to mention, I use WinXP.
EDITEDIT: My bad, I already found what the problem is. I had my Xbox 360 USB controller attached to the PC, when I unplugged it, the problem was instantly gone. Feel free to delete or move this post. Thanks anyways =)
Leave it up. Others will want to know the answer to the problem if they have it. I also had that problem, and the solution was also to unplug my XUSB controller.