Kleetus: Are you forcing anything via Catalyst Control Center?
Make sure it's all set to "Application Controlled".
I only have a 4890 with v11.4, but I don't have any graphics issues whatsoever.
As far as I could determine, everything is indeed "Application Controlled"
I also installed AMD newest game profiles, though frankly I gave up on trying to figure out how to make sure one is loaded. From what I could find after brief googling, they load automatically, though I'm rather uncertain whether that is accurate...
Would appreciate somebody more knowledgeable correcting me if that is not the case.
Unfortunately, it seems that until CD Projekt releases a patch fixing the issue with Crossfire (or, possibly, the Radeon 6800 series, based on Yourself's comment), I have the option of either playing on a single card and hope this does not occur (didn't have time to test this yet), or not play at all.
Even if the game did run on one card (at lower settings), I think I'll wait for the patch just for the sake of the eye candy.
I do hope they are working on this issue. So far they are ahead of everybody else in my books based on the support Witcher 1 received. Frankly, I bought Witcher 2 at full price mainly to support the developer. I learned quite a while ago to wait half a year or more with a purchase to avoid being a paying beta tester, or receiving only a part of the game at full price (looking at you, EA...).
Anyway, looks like the originally reported issue is here to stay for now. Le sigh.