Greywolf1: Same issue. "Please insert disk ..." message, but when I press "continue", the program continues as it should. Nothing serious, in my mind - not for me, at least.
But if it's not a general thing, then it's probably hard to investigate, and I'm not surprised that a solution hasn't been found yet. Nor would I expect the developers or technical support guys to give this issue a very high priority, unless they've got nothing more important to do - after all, it doesn't prevent us from playing, does it?
My PC is AMD, Vista 32bit, ATI Card, by the way.
Although I agree with you and it is not detremental to the game it's also like collecting a brand new car after its first service and finding it now has an annoying rattle every time you use the starter, it wasn't there beforehand and now it's very annoyingly there. Apart from the new rattle everything seems to be working OK. Do you just accept it even though it may irritate you or, do you go back to the service company and request that try to get rid of it?
People on the forum and here mainly just find it irritating but, I believe there are also those concerned that perhaps one day the game may fail to boot because there is no disk present or perhaps they they are concerned that they may now have the retail Witcher DRM on their computers that they wished to avoid by purchasing through GOG.