501105: Do I have to open the program and then start the game and press the chosen hotkey for it to work properly?
You right click the program and chose "run in administrative mode", then you select all 3 boxes and select either Steam or GOG version. Keep the program running and run witcher2.exe with "run in administrative mode" and it should work without hitting any hotkey or anything else.
Remember, don't run the launcher.exe, run the witcher2.exe when starting the game