Thwip: Most of the time I have my PC on I have Ventrilo running to talk with friends and family. I discovered today that Ventrilo's push-to-talk mechanism is disabled or overridden by Witcher 2 and doesn't work. (I loaded the Launcer to describe the ugly configurator to a friend.)
Next week when I can finally play Witcher 2 I guess there'll be no RL idle chatter. :(
Anyone know if Team Speak is the same?
I've spoken to my friend on Ventrilo using push to talk while playing TW2 in full screen all week long.
I'd look to your sound card/driver, and not at The Witcher here.
[Edit} have you tried a different PTT key? It may be that the key youve selected is problematic for TW2. I use f12, and it works fine.